منابع مشابه
Length matters
Mdm2 can mediate p53 ubiquitylation and degradation either in the form of the Mdm2 homodimer or Mdm2/MdmX heterodimer. The ubiquitin ligase activity of these complexes resides mainly in their respective RING finger domains and also requires adjacent C-terminal tails. So far, structural studies have failed to show significant differences between Mdm2 RING homodimers and Mdm2/MdmX RING heterodime...
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Professor Jenkinson and colleagues are to be congratulated for their recent randomized controlled trial of the effect on response of embedding the Picker Patient Experience questionnaire (PPE-15) within either a four or a 12 page questionnaire. Mailed questionnaires are widely used for data collection in health research, but because non-response reduces the effective sample size and can introdu...
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Obtaining an unbiased view of the phylogenetic composition and functional diversity within a microbial community is one central objective of metagenomic analysis. New technologies, such as 454 pyrosequencing, have dramatically reduced sequencing costs, to a level where metagenomic analysis may become a viable alternative to more-focused assessments of the phylogenetic (e.g., 16S rRNA genes) and...
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A recent study by Gabel et al. (2015) found that Mecp2, the gene mutated in Rett syndrome, represses long (> 100 kb) genes associated with neuronal physiology and connectivity by binding to methylated CA sites in DNA. This study adds to a growing body of literature implicating gene length and transcriptional mechanisms in neurodevelopmental and neurodegenerative disorders.
متن کاملLength matters in prostate cancer.
© The Canadian Journal of UrologyTM; 20(4); August 2013 Address correspondence to Dr. Theodorus H. Van der Kwast, Department of Pathology, Princess Margaret Cancer Center, 610 University Avenue, Toronto, ON M5G 2M9 Canada Length matters in prostate cancer Farshid Siadat, MD, Jenna Sykes, Theodorus H. Van der Kwast, MD Departments of Pathology and Statistics, Princess Margaret Cancer Center, Tor...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2012
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.20047